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What the Evidence Shows (and What It Doesn’t) A recent real-world study (n = 94) on semaglutide + cyanocobalamin (compounded) showed average weight loss of ~4.11 kg (≈4.6%) in 3 months , along with favorable reductions in fat mass and improvements in body composition PubMed However, large controlled trials of this exact combination are lacking

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Converting those to the units products are sold in is revealing: There is a legitimate reason a topical product is not formulated at 10⁻⁹ M: a molecule applied to intact skin must cross the stratum corneum, and only a fraction of what is applied reaches living tissue