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Hierarchical clustering of all DEGs further corroborated this observation, revealing clear demarcation between infected and uninfected samples alongside a polarized “red-blue” expression pattern—characteristic of directional reprogramming toward either pro-viral or anti-viral states ( Figure 3B )

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PQQ being a recognized natural antioxidant promotes mitochondrial biogenesis, strong anti-diabetic potential, neuroprotection, and cardioprotective effects (Qu et al., 2022)