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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46

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We found that atorvastatin, fluvastatin, lovastatin, pitavastatin, and simvastatin induced cell death in a dose- and time-dependent manner, but pravastatin and rosuvastatin did not (Figure 2A, S2A)