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In clinical studies, it has been administered in doses between 0.5mcg/kg and roughly 16,000mcg/kg for up to 2 weeks [42, 43]

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A large population-based cohort study published in 2024 demonstrated that both diagnosed and self-reported constipation were prospectively associated with an elevated risk of depression, suggesting that constipation may be an independent risk factor or prodromal symptom of depression (Yun et al., 2024)