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This point is highly relevant, as one of the central roles of Aβ is the modulation of synaptic plasticity (Parihar and Brewer, 2010), a process itself that is regulated by copper efflux into the synapse that can influence the excitability of NDMA, AMPA, and GABA receptors as well as vesicular trafficking (D’Ambrosi and Rossi, 2015)