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The Benefits of Glutathione | Health First Network

110 However, the role of the UPS is tissue specific, e.g., in muscle cells from insulin-resistant individuals, proteasome activity is increased, contributing to muscle protein degradation and atrophy

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[116], the increased production of superoxide radicals (O 2 •− ) resulting from T2D hyperglycemia can rapidly react with nitric oxide (NO) to produce peroxynitrite (ONOO − ), which can subsequently react with protein (and apolipoprotein) tyrosine residues to form 3-nitro-tyrosine (3-NT)