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The preclinical numbers are the only ones with any experimental basis: in rats, oral gavage 1.25-2.0 mg/kg/day (2.0 mg/kg was the effective dose), intraperitoneal 0.05-0.50 mg/kg/day (0.5 mg/kg effective), and intracerebroventricular 0.1-1.0 nmol, with intravenous dosing used principally in the pharmacokinetic arm from which the terminal half-life figures come
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These remedies not only improve metabolism but also play a role in tissue regeneration, mitochondrial efficiency, and immune system adjustments—showcasing the broad implications of focusing efforts toward cellular signaling pathways such as AMPK, PI3K/AKT, and mTOR