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Conversely, research has shown that supplementing with folic acid may reduce homocysteine levels and lower the risk of heart disease ( Supplementing with folic acid has also been shown to reduce other heart disease risk factors like high blood pressure

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Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested