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Research has found that quercetin, present in Xiao Yao San, targets the lipid metabolism-associated gene PTGS2, inhibits neuronal ferroptosis, and improves the immune response, thereby alleviating BCRD (36, 221)

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The failure of achieving a survival advantage along with serious tolerability issues created controversy over the real value of bevacizumab treatment in metastatic breast cancer and further brought its approval into question