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BPC-157 modulates GABA pathways in rat models (Sikirić et al., 2010), the same system targeted by zolpidem, eszopiclone, and benzodiazepines

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Key Mechanistic Differences# The mechanistic distinction is significant: Dihexa promotes structural synaptic plasticity through growth factor signaling (building new connections), while PE-22-28 modulates functional neuronal properties through ion channel blockade (changing how existing neurons fire)