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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Griffin D.O., Jensen A., Khan M., Chin J., Chin K., Saad J., Parnell R., Awwad C., Patel D
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In proteins, specific hydrogen-bond donors and an electropositive local environment tend to lower the pK a by stabilizing the thiolate, and a hydrophobic environment or an electronegative local environment tends to raise the pK a by destabilizing a negatively-charged as opposed to neutral form of the side chain (for a few specific examples of these effects, see [14, 30–32])