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However, within the cell, in the cytosol and mitochondria, the GPx system appears to be very efficient in the elimination of H 2 O 2 due to the low (100–200 μM) K m value of the enzyme [136] and the range of substrates [137]

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A feeling of warmth, pruritus, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioneurotic edema, cyanosis, pulmonary edema, and hemorrhage into the gastrointestinal tract have also been reported