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Telomerase is the enzyme responsible for maintaining and extending telomeres, the protective caps at the ends of chromosomes that shorten with each cell division

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A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]

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