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Supporting this model, peripheral blood mononuclear cells from women with chronic pelvic pain release significantly greater amounts of IL-1β following lipopolysaccharide-induced TLR4 activation, compared with pain-free controls, indicating a state of peripheral immune hyper-responsiveness and systemic neuroimmune sensitization (Evans et al., 2020

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10.1002/jor.21107 [DOI] [PubMed] [Google Scholar] Cesarec V., Becejac T., Misic M., Djakovic Z., Olujic D., Drmic D., et al