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From this Ikaros-mimicry bonsai library subjected to GluePCA, we recovered several known neo-substrates, including mTOR 17 , ZBED3 (refs

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Furthermore, the first three eigenvectors were collected from each MD simulation trajectory and plotted to demonstrate the residual displacement in the different conformations of the protein structure, where a gradient color change (from blue to white to red) specifies that there are regular leaps among the various conformation of protein structure throughout the trajectory (Fig