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4a, right) to provide histidine-rich sequences capable of destabilizing endosome membranes at acidic pH26,27

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9.2 Magnetic hyperthermia and MRI theranostics MNPs subjected to alternating magnetic fields (AMFs) generate localized heat through Néel relaxation and Brownian relaxation mechanisms, achieving therapeutic hyperthermia (42 °C–46 °C) that selectively damages tumor cells while sparing surrounding normal tissue ( 2 -weighted MRI contrast, enabling real-time monitoring of nanoparticle biodistribution and treatment response—a theranostic capability that is highly valuable for image-guided HCC therapy (Van et al., 2023)