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In the cardiac myocyte, glutathione deficiency fuels a vicious TNF/ sTNFR1/ oxidative stress/ neutral sphingomyelinase/ apoptosis cycle [18], [19], [34]–[36]

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Both DSIP and DSIP-CBBBP treatments increase serotonin levels significantly, suggesting their effectiveness in improving sleep effects, while CBBBP alone shows no significant impact on serum levels of melatonin, serotonin, dopamine, and glutamate

Glutathione is a very potent antioxidant that is naturally produced by the body (and the only one that is intracellular)