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Long-term dietary exposure to the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen can affect the physiology of common carp (Cyprinus carpio) on multiple levels, even at “environmentally relevant” concentrations - ScienceDirect

The first step we have is really the brain signalling down to the thyroid

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At the highest warfarin concentration tested (50 nM), carboxylation was undetectable (Figure 3C), which represented at least a 200-fold decrease in carboxylation