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These acute exacerbation events not only significantly impact patient quality of life but are also closely associated with progressive lung function decline and increased mortality risk (Chalmers et al., 2014)

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The same finding was not found in the randomized, double-blind, placebo-controlled trial that compared the use of high-dose NAC (1800 mg twice a day, totaling 3600 mg/day) versus placebo for 8 weeks in COPD patients

designed to enhance absorption