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Table of contents The most important caveat: no head-to-head trial exists Why cross-trial comparison is methodologically weak The weight loss numbers, contextualized Time-matched vs final-readout comparisons Side-by-side: efficacy, safety, availability, cost Mechanism differences and what they predict Liver fat: the area where retatrutide most clearly leads Side effects: where tirzepatide leads on tolerability The cardiovascular question The decision framework: today vs the future The contrary view: should anyone wait for retatrutide FAQ Sources The most important caveat: no head-to-head trial exists This article begins where most retatrutide vs tirzepatide articles end

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