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The Leu/Pro polymorphism (at SNP rs1050450, commonly referred to as Pro198Leu) shows an interesting gene–environment effect in that these allelic forms differ in their expression in response to selenium

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This protection is achieved through the stabilization of Solute Carrier Family 7 Member 11 (SLC7A11), which is the vital subunit of the cystine/glutamate antiporter (System Xc − )