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Research in chronic wound models—including diabetic and pressure ulcer experimental systems that had failed standard healing protocols—demonstrates that TB-500 administration achieves closure rates of 75-85% compared to 35-45% with standard approaches, highlighting potential for addressing impaired healing scenarios

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Major vessels congestion (i.e., inferior caval vein, superior mesenteric vein) was reversed to normal vessel presentation, and the failure of the collapsed azygos vein presented as the reactivated pathway for blood flow direct delivery [19,24,27,29,31,37,38,39,40]