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Tirzepatide: Nausea and vomiting during dose escalation Fatigue and occasional hypoglycemia (especially if combined with insulin or sulfonylureas) Potential risk of gallbladder issues due to rapid weight loss Cagrilintide: Mild nausea in first two weeks Occasional constipation or reduced appetite beyond comfort No significant hypoglycemia risk Both should be avoided during pregnancy, breastfeeding, or by individuals with personal/family history of medullary thyroid carcinoma (a class precaution for incretin-based therapies)