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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells

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3.6.2 Ferroptosis dysregulation drives RCC drug resistance Sorafenib, the first Food and Drug Administration (FDA)-approved multi-kinase inhibitor for metastatic ccRCC (253), was initially shown to induce ferroptosis by inhibiting SLC7A11 (254)