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Harpagoside, one of its active constituents, exerts neuroprotective effects by modulating endoplasmic reticulum–mitochondria coupling (MAMs), suppressing IP3R1/GRP75/VDAC1 complex expression, and maintaining neuronal calcium homeostasis

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Cohen shares a list of what companies should be testing and including on its COA: pH levels Presence of any endotoxins Sterility Purity percentage (ideally, 99% or higher of BPC-157) and what the remaining percentage includes Materials used to make the glass vials, as some can leach heavy metals Testing both before and after lyophilization (freeze-drying) Be wary of companies that can’t produce or don't have a COA