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topiramate extended-release for obesity along with their antidepressants (e.g., SSRIs or SNRIs, but not MAOIs or TCAs) as long as the antidepressant dose had been stable for at least 3 months prior to the initiation of phentermine, and the patient did not have suicidal ideation or more than 1 episode of major depression documented

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Most subcutaneous research protocols use 100 to 500 micrograms per injection, typically administered in the evening 30 to 60 minutes before sleep