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CURRENT THERAPEUTIC PERSPECTIVES Non-pharmacological treatments Non-pharmacological treatments remain as the cornerstone of knee osteoarthritis (KOA) management and are recommended as first-line therapies by the international guidelines, including Osteoarthritis Research Society International (OARSI) and the American College of Rheumatology/Arthritis Foundation (Bannuru et al ., 2019

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Drug Disc 22 (8), 1–18