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Single-dose pharmacokinetic parameters (maximum observed plasma concentration [ C max ], time to maximum plasma concentration [ T max ], area under the concentration–time curve to the last observation [AUC (0– T ) ], area under the concentration–time curve to infinity [AUC (INF) ], terminal half-life [ T 1/2 ], and renal clearance [CLR]) were derived from plasma concentration versus time and urinary excretion data

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