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As one review notes, enzymes in GSH biosynthesis maintain intracellular ROS detoxification, and their inhibition sensitizes cells to oxidative stress

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Notably, incubating peripheral whole blood cultures with vitamin B12 resulted in the normalization of CCL11 expression, the increase of the neuroprotective HGF and the decrease CSF2 and CXCL10 mRNA levels in leukocytes from individuals with persistent VCD (Fig