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Conversely, on the paternal allele, the heavily methylated ICR facilitates IGF-2 transcription and results in the silencing of H19 (40)

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at the same time, since the intracerebral hematoma releases hemoglobin (Hb)-based neurotoxin (Wang 2010), the neural damages secondary to perihematomal edema (PHE) that is caused by BBB disruption also occur in the brain parenchyma, becoming an important cause of morbidity and mortality in patients (Jeon et al., 2021)